Title
PROGINS Alu insertion and human genomic diversity
Document Type
Article
Publication Date
4-25-2002
Abstract
A polymorphic Alu element belonging to the young Ya5 subfamily of Alu repeats located in the progesterone receptor gene has been characterized. Using a polymerase chain reaction (PCR)-based assay, the genetic diversity associated with the PROGINS Alu repeat was determined in a diverse array of human populations. The level of insertion polymorphism associated with PROGINS suggests that it will be a useful marker for the study of human evolution. In addition, we determined the distribution of the PROGINS Alu insertion in two groups of women from greater New Orleans, LA with breast cancer. The PROGINS Alu insertion was not associated with breast cancer in the populations tested. © 2002 Elsevier Science B.V. All rights reserved.
Publication Source (Journal or Book title)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
First Page
137
Last Page
141
Recommended Citation
Donaldson, C., Crapanzano, J., Watson, J., Levine, E., & Batzer, M. (2002). PROGINS Alu insertion and human genomic diversity. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 501 (1-2), 137-141. https://doi.org/10.1016/S0027-5107(02)00015-5