Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants
Homologues of the yeast ubiquitin ligase-associated protein SGT1 are required for disease resistance in plants mediated by nucleotide-binding site/leucine-rich repeat (NBS-LRR) proteins. Here, by silencing SGT1 in Nicotiana benthamiana, we extend these findings and demonstrate that SGT1 has an unexpectedly general role in disease resistance. It is required for resistance responses mediated by NBS-LRR and other R proteins in which pathogen-derived elicitors are recognized either inside or outside the host plant cell. A requirement also exists for SGT1 in nonhost resistance in which all known members of a host species are resistant against every characterized isolate of a pathogen. Our findings show that silencing SGT1 affects diverse types of disease resistance in plants and support the idea that R protein-mediated and nonhost resistance may involve similar mechanisms.
Publication Source (Journal or Book title)
Proceedings of the National Academy of Sciences of the United States of America
Peart, J., Lu, R., Sadanandom, A., Malcuit, I., Moffett, P., Brice, D., Schauser, L., Jaggard, D., Xiao, S., Coleman, M., Dow, M., Jones, J., Shirasu, K., & Baulcombe, D. (2002). Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants. Proceedings of the National Academy of Sciences of the United States of America, 99 (16), 10865-10869. https://doi.org/10.1073/pnas.152330599