It is generally thought that only a few Alu elements are capable of retrotransposition and that these 'master' sources produce inactive copies. Here, we use a network phylogenetic approach to demonstrate that recently integrated human-specific Alu subfamilies typically contain 10-20% of secondary source elements that contributed 20-40% of all subfamily members. This multiplicity of source elements provides new insight into the remarkably successful amplification strategy of the Alu family.
Publication Source (Journal or Book title)
Trends in Genetics
Cordaux, R., Hedges, D., & Batzer, M. (2004). Retrotransposition of Alu elements: How many sources?. Trends in Genetics, 20 (10), 464-467. https://doi.org/10.1016/j.tig.2004.07.012