Title

Evidence for a malarial parasite interaction site on the major transmembrane protein of the human erythrocyte

Document Type

Article

Publication Date

1-1-1985

Abstract

Soluble oligosaccharides derived from the surface of human erythrocytes were tested for their ability to competitively inhibit invasion of erythrocytes by Plasmodium falciparum, a malarial parasite. Invasion was most effectively inhibited by erythroglycan, a carbohydrate component of the band 3 transmembrane protein. The lactosamine chains of erythroglycan contributed much of the inhibitory activity. This indication of a primary parasite interaction site on band 3 supports a role for this protein in mediating the radical alterations of the erythrocyte cytoskeleton that accompany invasion.

Publication Source (Journal or Book title)

Science

First Page

75

Last Page

77

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