Title

Evolutionary and biomedical insights from the rhesus macaque genome

Authors

Richard A. Gibbs, Baylor College of Medicine
Jeffrey Rogers, Texas Biomedical Research Institute
Michael G. Katze, University of Washington, Seattle
Roger Bumgarner, University of Washington, Seattle
George M. Weinstock, Baylor College of Medicine
Elaine R. Mardis, Washington University in St. Louis
Karin A. Remington, J. Craig Venter Institute
Robert L. Strausberg, J. Craig Venter Institute
J. Craig Venter, J. Craig Venter Institute
Richard K. Wilson, Washington University in St. Louis
Mark A. Batzer, Louisiana State University
Carlos D. Bustamante, Cornell University
Evan E. Eichler, University of Washington, Seattle
Matthew W. Hahn, Luddy School of Informatics, Computing, and Engineering
Ross C. Hardison, Pennsylvania State University
Kateryna D. Makova, Pennsylvania State University
Webb Miller, Pennsylvania State University
Aleksandar Milosavljevic, Baylor College of Medicine
Robert E. Palermo, University of Washington, Seattle
Adam Siepel, Cornell University
James M. Sikela, University of Colorado Health Sciences Center
Tony Attaway, Baylor College of Medicine
Stephanie Bell, Baylor College of Medicine
Kelly E. Bernard, Washington University in St. Louis
Christian J. Buhay, Baylor College of Medicine
Mimi N. Chandrabose, Baylor College of Medicine
Marvin Dao, Baylor College of Medicine
Clay Davis, Baylor College of Medicine
Kimberly D. Delehaunty, Washington University in St. Louis
Yan Ding, Baylor College of Medicine
Huyen H. Dinh, Baylor College of Medicine
Shannon Dugan-Rocha, Baylor College of Medicine
Lucinda A. Fulton, Washington University in St. Louis
Ramatu Ayiesha Gabisi, Baylor College of Medicine

Document Type

Article

Publication Date

4-13-2007

Abstract

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

Publication Source (Journal or Book title)

Science

First Page

222

Last Page

234

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