Kim C. Worley, Baylor College of Medicine
Wesley C. Warren, Washington University in St. Louis
Jeffrey Rogers, Baylor College of Medicine
Devin Locke, Washington University in St. Louis
Donna M. Muzny, Baylor College of Medicine
Elaine R. Mardis, Washington University in St. Louis
George M. Weinstock, Baylor College of Medicine
Suzette D. Tardif, The University of Texas at San Antonio
Kjersti M. Aagaard, Baylor College of Medicine
Nicoletta Archidiacono, Università degli Studi di Bari
Nirmala Arul Rayan, A-Star, Genome Institute of Singapore
Mark A. Batzer, Louisiana State University
Kathryn Beal, Wellcome Sanger Institute
Brona Brejova, Comenius University
Oronzo Capozzi, Università degli Studi di Bari
Saverio B. Capuano, Wisconsin National Primate Research Center
Claudio Casola, Indiana University Bloomington
Mimi M. Chandrabose, Baylor College of Medicine
Andrew Cree, Baylor College of Medicine
Marvin Diep Dao, Baylor College of Medicine
Pieter J. De Jong, Children's Hospital Oakland Research Institute
Ricardo Cruz-Herrera del Rosario, A-Star, Genome Institute of Singapore
Kim D. Delehaunty, Washington University in St. Louis
Huyen H. Dinh, Baylor College of Medicine
Evan E. Eichler, University of Washington, Seattle
Stephen Fitzgerald, Wellcome Sanger Institute
Paul Flicek, Wellcome Sanger Institute
Catherine C. Fontenot, Louisiana State University
R. Gerald Fowler, Baylor College of Medicine
Catrina Fronick, Washington University in St. Louis
Lucinda A. Fulton, Washington University in St. Louis
Robert S. Fulton, Washington University in St. Louis
Ramatu Ayiesha Gabisi, Baylor College of Medicine
Daniel Gerlach, Université de Genève Faculté de Médecine

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We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application. © 2014 Nature America, Inc.

Publication Source (Journal or Book title)

Nature Genetics

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