APOE ε4, rated life experiences, and affect among centenarians

Peter Martin, Iowa State University
S. Michal Jazwinski, Tulane University School of Medicine
Adam Davey, Temple University
Robert C. Green, Brigham and Women's Hospital
Maurice Macdonald, Kansas State University
Jennifer A. Margrett, Iowa State University
Ilene C. Siegler, Duke University School of Medicine
Jonathan Arnold, University of Georgia
John L. Woodard, Wayne State University
Mary Ann Johnson, College of Family & Consumer Sciences
Sangkyu Kim, Tulane University School of Medicine
Jianliang Dai, Tulane University School of Medicine
Li Li, LSUHSC School of Medicine
Mark A. Batzer, Louisiana State University
Leonard W. Poon, University of Georgia

Abstract

Objectives: The purpose of this study was to assess the relationship between apolipoprotein E (APOE), life events and engagement, and subjective well-being (as measured by positive and negative affect) among centenarians. Based on the life stress paradigm, we predicted that higher levels of stress would allow APOE to influence positive and negative affect.Method: 196 centenarians and near-centenarians (98 years and older) of the Georgia Centenarian Study participated in this research. The APOE, positive and negative affect, the number of recent (last 2 years) and lifelong (more than 20 years prior to testing) events, as well as a number of life engagement tasks were assessed.Results: Results suggested that centenarians carrying the APOE ε4 allele rated lower in positive affect, the number of lifelong events, and in engaged lifestyle, when compared to centenarians without the APOE ε4 allele (t = 3.43, p <.01; t = 3.19, p <.01; and t = 2.33, p <.05, respectively). Blockwise multiple regressions indicated that the APOE ε4 predicted positive but not negative affect after controlling for demographics. Gene-environment interactions were obtained for the APOE ε4 and lifelong events, suggesting that carriers of the APOE ε4 allele had higher scores of negative affect after having experienced more events, whereas noncarriers had reduced negative affect levels after having experienced more events.Conclusion: APOE ε4 is directly related to positive affect and is related to negative affect in interaction with life events. © 2013 Taylor & Francis.