Authors

Lucia Carbone, Oregon Health & Science University
R. Alan Harris, Baylor College of Medicine
Sante Gnerre, Nabsys
Krishna R. Veeramah, The University of Arizona
Belen Lorente-Galdos, Universitat Pompeu Fabra Barcelona
John Huddleston, University of Washington, Seattle
Thomas J. Meyer, Oregon Health & Science University
Javier Herrero, European Bioinformatics Institute
Christian Roos, Deutsches Primatenzentrum
Bronwen Aken, European Bioinformatics Institute
Fabio Anaclerio, Università degli Studi di Bari
Nicoletta Archidiacono, Università degli Studi di Bari
Carl Baker, University of Washington, Seattle
Daniel Barrell, European Bioinformatics Institute
Mark A. Batzer, Louisiana State University
Kathryn Beal, European Bioinformatics Institute
Antoine Blancher, Universite Paul Sabatier Toulouse III
Craig L. Bohrson, Johns Hopkins School of Medicine
Markus Brameier, Deutsches Primatenzentrum
Michael S. Campbell, The University of Utah
Oronzo Capozzi, Università degli Studi di Bari
Claudio Casola, Texas A&M University
Giorgia Chiatante, Università degli Studi di Bari
Andrew Cree, Baylor College of Medicine
Annette Damert, Universitatea Babes-Bolyai din Cluj-Napoca
Pieter J. De Jong, Children's Hospital Oakland Research Institute
Laura Dumas, University of Colorado School of Medicine
Marcos Fernandez-Callejo, Universitat Pompeu Fabra Barcelona
Paul Flicek, European Bioinformatics Institute
Nina V. Fuchs, Max Delbruck Center for Molecular Medicine
Ivo Gut, Universitat de Barcelona
Marta Gut, Universitat de Barcelona
Matthew W. Hahn, Luddy School of Informatics, Computing, and Engineering
Jessica Hernandez-Rodriguez, Universitat Pompeu Fabra Barcelona
LaDeana W. Hillier, Washington University School of Medicine
Robert Hubley, Institute for Systems Biology
Bianca Ianc, Babes-Bolyai University
Zsuzsanna Izsvák, Max Delbrück Center for Molecular Medicine
Nina G. Jablonski, The Pennsylvania State University
Laurel M. Johnstone, University of Arizona
Anis Karimpour-Fard, University of Colorado School of Medicine
Miriam K. Konkel, Louisiana State University and Agricultural and Mechanical College
Dennis Kostka, University of Pittsburgh School of Medicine
Nathan H. Lazar, Oregon Health & Science University
Sandra L. Lee, Human Genome Sequencing Center
Lora R. Lewis, Human Genome Sequencing Center
Yue Liu, Human Genome Sequencing Center
Devin P. Locke, Washington University School of Medicine
Swapan Mallick, Harvard Medical School
Fernando L. Mendez, University of Arizona
Matthieu Muffato, European Molecular Biology Laboratory
Lynne V. Nazareth, Human Genome Sequencing Center
Kimberly A. Nevonen, Oregon National Primate Research Center
Majesta O'Bleness, University of Colorado School of Medicine
Cornelia Ochis, Babes-Bolyai University
Duncan T. Odom, European Bioinformatics Institute
Katherine S. Pollard, University of California, Gladstone Institutes
Javier Quilez, Institut de Biologia Evolutiva
David Reich, Harvard Medical School
Mariano Rocchi, University of Bari
Gerald G. Schumann, Oregon Health and Science University
Stephen Searle, European Bioinformactics Institute
James M. Sikela, University of Colorado School of Medicine
Gabriella Skollar, Gibbon Conservation Center
Arian Smit, The Genome Center at Washington University
Kemal Sonmez, Oregon Health & Science University
Boudewijn ten Hallers, Children's Hospital Oakland Research Institute
Elizabeth Terhune, Oregon National Primate Research Center
Gregg W. C. Thomas, Indiana University
Brygg Ullmer, Louisiana State University and Agricultural and Mechanical College
Mario Ventura, University of Bari
Jerilyn A. Walker, Louisiana State University and Agricultural and Mechanical College
Jeffrey D. Wall, Institute for Human Genetics
Lutz Walter, Leibniz Institute for Primate Research
Michelle C. Ward, University of Cambridge
Sarah J. Wheelan, The Johns Hopkins University School of Medicine
Christopher W. Whelan, Oregon Health & Science University
Simon White, European Bioinformatics Institute
Larry J. Wilhelm, Oregon National Primate Research Center
August E. Woerner, University of Arizona
Mark Yandell, University of Utah
Baoli Zhu, Children’s Hospital Oakland Research Institute
Michael F. Hammer, University of Arizona
Tomas Marques-Bonet, Institut de Biologia Evolutiva
Evan E. Eichler, University of Washington School of Medicine
Lucinda Fulton, Washington University School of Medicine
Catrina Fronick, Washington University School of Medicine
Donna M. Muzny, Baylor College of Medicine
Wesley C. Warren, Washington University School of Medicine
Kim C. Worley, Baylor College of Medicine
Jeffrey Rogers, Baylor College of Medicine
Richard K. Wilson, Washington University School of Medicine
Richard A. Gibbs, Baylor College of Medicine

Document Type

Article

Publication Date

9-11-2014

Abstract

©2014 Macmillan Publishers Limited. All rights reserved. Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly and analysis of a northern white-cheeked gibbon (Nomascus leucogenys) genome. We describe the propensity for a gibbon-specific retrotransposon (LAVA) to insert into chromosome segregation genes and alter transcription by providing a premature termination site, suggesting a possible molecular mechanism for the genome plasticity of the gibbon lineage. We further show that the gibbon genera (Nomascus, Hylobates, Hoolock and Symphalangus) experienced a near-instantaneous radiation ∼5 million years ago, coincident with major geographical changes in southeast Asia that caused cycles of habitat compression and expansion. Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.

Publication Source (Journal or Book title)

Nature

First Page

195

Last Page

201

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