Title

GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs

Document Type

Article

Publication Date

7-23-1996

Abstract

Analogs of GPI membrane anchor precursors were prepared from chiral inositol 1 and evaluated as substrates in rodent and trypanosomal cell-free incubates. Di-octanoyl GlcNα-PI 5b was an efficient mannose acceptor whereas di-palmitoyl GlcNα-PI 5a was unexpectedly refractory. Di-octanoyl β-anomer 8 was mannosylated only under conditions that permitted acylation of the inositol residue.

Publication Source (Journal or Book title)

Bioorganic and Medicinal Chemistry Letters

First Page

1715

Last Page

1718

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