GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs
Analogs of GPI membrane anchor precursors were prepared from chiral inositol 1 and evaluated as substrates in rodent and trypanosomal cell-free incubates. Di-octanoyl GlcNα-PI 5b was an efficient mannose acceptor whereas di-palmitoyl GlcNα-PI 5a was unexpectedly refractory. Di-octanoyl β-anomer 8 was mannosylated only under conditions that permitted acylation of the inositol residue.
Publication Source (Journal or Book title)
Bioorganic and Medicinal Chemistry Letters
Ye, J., Doerrler, W., Lehrman, M., & Falck, J. (1996). GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs. Bioorganic and Medicinal Chemistry Letters, 6 (14), 1715-1718. https://doi.org/10.1016/0960-894X(96)00306-X