Title
Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator
Document Type
Article
Publication Date
6-1-1997
Abstract
Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.
Publication Source (Journal or Book title)
Trends in Biochemical Sciences
First Page
207
Last Page
210
Recommended Citation
Hidalgo, E., Ding, H., & Demple, B. (1997). Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator. Trends in Biochemical Sciences, 22 (6), 207-210. https://doi.org/10.1016/S0968-0004(97)01068-2