Title

Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator

Document Type

Article

Publication Date

6-1-1997

Abstract

Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.

Publication Source (Journal or Book title)

Trends in Biochemical Sciences

First Page

207

Last Page

210

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