Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator
Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.
Publication Source (Journal or Book title)
Trends in Biochemical Sciences
Hidalgo, E., Ding, H., & Demple, B. (1997). Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator. Trends in Biochemical Sciences, 22 (6), 207-210. https://doi.org/10.1016/S0968-0004(97)01068-2