Title

Redox control of human mitochondrial outer membrane protein mitoneet [2FE-2S] clusters by biological thiols and hydrogen peroxide

Document Type

Article

Publication Date

2-14-2014

Abstract

Background: MitoNEET is a target of the type II diabetes drug pioglitazone and contains a [2Fe-2S] cluster. Results: The mitoNEET [2Fe-2S] cluster can be reduced by biological thiols and reversibly oxidized by hydrogen peroxide. Conclusion: The redox state of mitoNEET [2Fe-2S] clusters can be regulated by thiols and oxidative signals. Significance: MitoNEET may act as a redox sensor to modulate mitochondrial functions. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..

Publication Source (Journal or Book title)

Journal of Biological Chemistry

First Page

4307

Last Page

4315

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