Document Type
Article
Publication Date
2-14-2014
Abstract
Background: MitoNEET is a target of the type II diabetes drug pioglitazone and contains a [2Fe-2S] cluster. Results: The mitoNEET [2Fe-2S] cluster can be reduced by biological thiols and reversibly oxidized by hydrogen peroxide. Conclusion: The redox state of mitoNEET [2Fe-2S] clusters can be regulated by thiols and oxidative signals. Significance: MitoNEET may act as a redox sensor to modulate mitochondrial functions. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Publication Source (Journal or Book title)
Journal of Biological Chemistry
First Page
4307
Last Page
4315
Recommended Citation
Landry, A., & Ding, H. (2014). Redox control of human mitochondrial outer membrane protein mitoneet [2FE-2S] clusters by biological thiols and hydrogen peroxide. Journal of Biological Chemistry, 289 (7), 4307-4315. https://doi.org/10.1074/jbc.M113.542050