Background: MitoNEET is a target of the type II diabetes drug pioglitazone and contains a [2Fe-2S] cluster. Results: The mitoNEET [2Fe-2S] cluster can be reduced by biological thiols and reversibly oxidized by hydrogen peroxide. Conclusion: The redox state of mitoNEET [2Fe-2S] clusters can be regulated by thiols and oxidative signals. Significance: MitoNEET may act as a redox sensor to modulate mitochondrial functions. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Publication Source (Journal or Book title)
Journal of Biological Chemistry
Landry, A., & Ding, H. (2014). Redox control of human mitochondrial outer membrane protein mitoneet [2FE-2S] clusters by biological thiols and hydrogen peroxide. Journal of Biological Chemistry, 289 (7), 4307-4315. https://doi.org/10.1074/jbc.M113.542050