Title
Iron homeostasis and iron-sulfur cluster assembly in Escherichia coli
Document Type
Article
Publication Date
8-12-2016
Abstract
© 2016 John Wiley & Sons, Inc. All rights reserved. Throughout evolution, organisms have adapted a set of dedicated proteins for iron-sulfur cluster biogenesis. Among the identified iron-sulfur cluster assembly proteins in Escherichia coli, IscA has a unique and strong iron-binding activity, and the iron-bound IscA can readily provide iron for iron-sulfur cluster assembly in proteins in vitro under aerobic conditions. IscA also has a high binding affinity for copper, and excess copper competes for the iron-binding sites in IscA and effectively blocks the IscA-mediated iron-sulfur cluster biogenesis. It is thus postulated that IscA may act as an iron chaperone to recruit intracellular iron and deliver iron for iron-sulfur cluster biogenesis under aerobic conditions.
Publication Source (Journal or Book title)
Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria
First Page
203
Last Page
214
Recommended Citation
Ding, H. (2016). Iron homeostasis and iron-sulfur cluster assembly in Escherichia coli. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 1, 203-214. https://doi.org/10.1002/9781119004813.ch17