"Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by " by Jorge A. Belgodere, Dongwan Son et al.

Faculty Publications

Title

Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites

Authors

Jorge A. Belgodere, Department of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Dongwan Son, Department of Chemistry and Chemical Engineering, Inha University, Incheon 22212, Republic of Korea.
Bokyoung Jeon, Department of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Jongwon Choe, Department of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Anna C. Guidry, Department of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Adam X. Bao, Department of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Syed A. Zamin, Department of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, United States.

Document Type

Article

Publication Date

6-14-2021

Abstract

We report the use of phenolic functional groups of lignosulfonate to impart antioxidant properties and the cell binding domains of gelatin to enhance cell adhesion for poly(ethylene glycol) (PEG)-based scaffolds. Chemoselective thiol-ene chemistry was utilized to form composites with thiolated lignosulfonate (TLS) and methacrylated fish gelatin (fGelMA). Antioxidant properties of TLS were not altered after thiolation and the levels of antioxidation were comparable to those of -ascorbic acid. PEG-fGelMA-TLS composites significantly reduced the difference in , , , and genes between high-scarring and low-scarring hdFBs, providing the potential utility of TLS to attenuate fibrotic responses.

Publication Source (Journal or Book title)

ACS biomaterials science & engineering

First Page

2212

Last Page

2218

Recommended Citation

Belgodere, J. A., Son, D., Jeon, B., Choe, J., Guidry, A. C., Bao, A. X., & Zamin, S. A. (2021). Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites. ACS biomaterials science & engineering, 7 (6), 2212-2218. https://doi.org/10.1021/acsbiomaterials.1c00427

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