Topical nanodelivery system of lutein for the prevention of selenite-induced cataractTopical nanodelivery system of lutein for the prevention of selenite-induced cataract
Cataracts are responsible for half of the world blindness, surgery being the only viable treatment. Lutein, a naturally occurring carotenoid in the eye, has the potential to reduce cataract progression by protecting the eye from photo-oxidative stress. To restore the eye's natural line of defense against photo-oxidative stress, a formulation was developed using zein and poly(lactic-co-glycolic acid) nanoparticles (NPs) embedded in an optimized bioadhesive thermosensitive gel for the delivery of lutein via topical application. Cataracts were induced in Crl:WI rats via selenite injection at 13 days post-partum, followed by 7 days of treatment with free lutein or lutein-loaded NPs administered orally or topically. Cataract severity was significantly reduced in rats treated with topical applications of lutein-loaded NPs compared to the positive control, while no significant differences were observed in rats treated with other lutein formulations including oral and topically applied free lutein.
Publication Source (Journal or Book title)
Nanomedicine : nanotechnology, biology, and medicine
Bodoki, E., Vostinaru, O., Samoila, O., Dinte, E., Bodoki, A. E., Swetledge, S., Astete, C. E., & Sabliov, C. M. (2019). Topical nanodelivery system of lutein for the prevention of selenite-induced cataractTopical nanodelivery system of lutein for the prevention of selenite-induced cataract. Nanomedicine : nanotechnology, biology, and medicine, 15 (1), 188-197. https://doi.org/10.1016/j.nano.2018.09.016