Lignin-Graft-Poly(lactic--glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis
A lignin-graft-poly(lactic--glycolic) acid (PLGA) biopolymer was synthesized with two types of lignin (LGN), alkaline lignin (ALGN) and sodium lignosulfonate (SLGN), at different (A/S)LGN/PLGA ratios (1:2, 1:4, and 1:6 w/w). H NMR and Fourier-transform infrared spectroscopy (FT-IR) confirmed the conjugation of PLGA to LGN. The (A/S)LGN-graft-PLGA biopolymers were used to form nanodelivery systems suitable for entrapment and delivery of drugs for disease treatment. The LGN-graft-PLGA NPs were generally small (100-200 nm), increased in size with the amount of PLGA added, monodisperse, and negatively charged (-48 to -60 mV). Small-angle scattering data showed that particles feature a relatively smooth surface and a compact spherical structure with a distinct core and a shell. The core size and shell thickness varied with the LGN/PLGA ratio, and at a 1:6 ratio, the particles deviated from the core-shell structure to a complex internal structure. The newly developed (A/S)LGN-graft-PLGA NPs are proposed as a potential delivery system for applications in biopharmaceutical, food, and agricultural sectors.
Publication Source (Journal or Book title)
Astete, C. E., De Mel, J. U., Gupta, S., Noh, Y., Bleuel, M., Schneider, G. J., & Sabliov, C. M. (2020). Lignin-Graft-Poly(lactic--glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis. ACS omega, 5 (17), 9892-9902. https://doi.org/10.1021/acsomega.0c00168