Title

Perkinsus marinus extracellular protease modulates survival of Vibrio vulnificus in eastern oyster (Crassostrea virginica) hemocytes

Document Type

Article

Publication Date

1-1-1999

Abstract

The in vitro effects of the Perkinsus marinus serine protease on the intracellular survival of Vibrio vulnificus in oyster hemocytes were examined by using a time-course gentamicin internalization assay. Results showed that protease-treated hemocytes were initially slower to internalize V. vulnificus than untreated hemocytes. After 1 h, the elimination of K vulnificus by treated hemocytes was significantly suppressed compared with hemocytes infected with invasive and noninvasive controls. Our data suggest that the serine protease produced by P. marinus suppresses the vibriocidal activity of oyster hemocytes to effectively eliminate V. vulnificus, potentially leading to conditions favoring higher numbers of vibrios in oyster tissues.

Publication Source (Journal or Book title)

Applied and Environmental Microbiology

First Page

4261

Last Page

4263

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