Title

Effect of the ionophore monensin on herpes simplex virus Type 1-induced cell fusion, glycoprotein synthesis, and virion infectivity

Document Type

Article

Publication Date

1-1-1983

Abstract

The ionophore monensin inhibited the formation of mature, fully glycosylated glycoproteins gB, gC, and gD during herpes simplex virus type 1 infection of human embryonic lung cells. Underglycosylated forms, including the apparent high-mannose precursor forms of the major glycoproteins, appeared. Monensin inhibited virus-induced cell fusion. Infectious virions produced in the presence of monensin appeared to contain predominantly underglycosylated glycoproteins. © 1983 S. Karger AG, Basel.

Publication Source (Journal or Book title)

Intervirology

First Page

56

Last Page

60

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