Title
Gut fermentation induced by a resistant starch rich whole grain diet explains serum concentration of dihydroferulic acid and hippuric acid in a model of ZDF rats
Document Type
Article
Publication Date
2-1-2019
Abstract
© 2019 Elsevier Ltd This study aimed at assessing the influence of an 11 weeks intervention with a resistant starch-enriched whole grain diet (HI-RS-WG, 25% RS) compared to a WG control diet (LOW-RS-WG, 6.9% RS) on serum profile of polyphenols (PPs) in 20 Zucker Diabetic Fatty rats. Five PPs were identified and quantified in serum samples of rats belonging to both intervention groups. HI-RS-WG rats had 2.6 folds higher serum concentrations of total PPs than LOW-RS-WG rats. An explorative data reduction approach, based on the Principal Component Analysis identified two principal components related to the gut microbiota fermentation and food intake, respectively. Results showed that the abundance of hippuric acid and dihydroferulic acid in HI-RS-WG rats was explained by the stronger gut microbiota fermentation in those rats than in LOW-RS-WG rats.
Publication Source (Journal or Book title)
Journal of Functional Foods
First Page
286
Last Page
291
Recommended Citation
Vitaglione, P., Mennella, I., Ferracane, R., Goldsmith, F., Guice, J., Page, R., Raggio, A., Coulon, D., Martin, R., & Keenan, M. (2019). Gut fermentation induced by a resistant starch rich whole grain diet explains serum concentration of dihydroferulic acid and hippuric acid in a model of ZDF rats. Journal of Functional Foods, 53, 286-291. https://doi.org/10.1016/j.jff.2018.12.041