Repeated acquisition of response sequences: Effects of d-amphetamine and chlorpromazine

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Pigeons obtained food by making 4 responses on 3 keys in a specified sequence, e.g., left, right, center, right. All 3 keys were the same color throughout the response sequence. Under the learning condition, the four-response sequence was changed from session to session. After learning (within-session error reduction) had stabilized, this baseline of repeated acquisition was used to assess the effects of varying doses of d-amphetamine and chlorpromazine. For comparison, the drug tests were also conducted under a performance condition in which the four-response sequence was the same from session to session. Increases in total errors and pausing were obtained at the largest dose of each drug under both the learning and performance conditions. Under the learning condition, the error rate decreased across trials within each session, but the degree of negative acceleration was less in the drug sessions than in the control sessions. In contrast, under the performance condition, the error rate was relatively constant across trials, but was higher in the drug sessions than in the control sessions. © 1974.

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Pharmacology, Biochemistry and Behavior

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