Title

SELECTIVE ANTAGONISM OF THE RATE‐DECREASING EFFECT OF d‐AMPHETAMINE BY CHLORPROMAZINE IN A REPEATED‐ACQUISITION TASK

Document Type

Article

Publication Date

1-1-1980

Abstract

Pigeons acquired a different four‐response chain each session by responding sequentially on three keys in the presence of four colors. The response chain was maintained by food presentation under a fixed‐ratio schedule. When d‐amphetamine was administered alone, the overall response rate decreased and the percent errors increased with increasing doses. When a small dose of chlorpromazine, which was ineffective when given alone, was administered in combination with d‐amphetamine, the rate‐decreasing effect was antagonized. The antagonism was selective, however, in that the error‐increasing effect of d‐amprotamine was augmented by chlorpromazine. The nature of the joint effect of the two drugs thus depended on the behavioral measure: rate vs. accuracy. 1980 Society for the Experimental Analysis of Behavior

Publication Source (Journal or Book title)

Journal of the Experimental Analysis of Behavior

First Page

87

Last Page

92

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