Title

SELECTIVE ANTAGONISM OF THE ERROR‐INCREASING EFFECT OF MORPHINE BY NALOXONE IN A REPEATED‐ACQUISITION TASK

Document Type

Article

Publication Date

1-1-1981

Abstract

Pigeons acquired a different four‐response chain each session by responding sequentially on three keys in the presence of four colors. The response chain was maintained by food presentation under a fixed‐ratio schedule. Errors produced a brief timeout but did not reset the chain. When either morphine or naloxone was administered alone, the overall response rate decreased with increasing doses. The rate‐decreasing effect was accompanied by an increase in percent errors with morphine but not with naloxone. Both effects of morphine were antagonized by doses of naloxone that were ineffective when given alone. The antagonism was selective in that naloxone (3 mg/kg) completely blocked the error‐increasing effect but not the rate‐decreasing effect of the higher doses of morphine. The view that naloxone is a specific narcotic antagonist was supported by the finding that naloxone failed to antagonize the rate‐decreasing and error‐increasing effects of d‐amphetamine, pentobarbital, and phencyclidine. 1981 Society for the Experimental Analysis of Behavior

Publication Source (Journal or Book title)

Journal of the Experimental Analysis of Behavior

First Page

371

Last Page

380

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