Title

Thyroid stimulating hormone and prolactin secretion after thyrotropin releasing hormone administration to mares: Dose response during anestrus in winter and during estrus in summer

Document Type

Article

Publication Date

1-1-1984

Abstract

The response of thyroid stimulating hormone (TSH) and prolactin (PRL) concentrations to administration of thyrotropin releasing hormone (TRH) was determined in light-horse mares during the anestrous season (winter) and during estrus (standing heat) in the summer. Within each season, mares (4/group) were treated with either saline (controls) or one of four doses of TRH (80, 400, 2,000 or 10,000 ug) intravenously. Samples of blood were drawn at -15, -.5, 15, 30, 45, 60, 90, 120, 180 and 240 min relative to TRH injection. Concentrations of TSH and PRL in pre-TRH samples were greater (P<.05) in anestrous mares during winter than in estrous mares during summer. Concentrations of TSH increased (P<.05) within 30 min after administration of TRH and remained elevated during the 4-hr sampling period. The maximal net change in TSH concentrations and the area under the response curve were greatest for 2,000 ug of TRH; 80 ug did not produce a significant TSH response. There was no interaction (P >.10) between reproductive state and TRH dose for TSH concentrations. Concentrations of PRL were not significantly affected by any TRH dose during either season. It appears that mares differ from many mammalian species in that they do not respond to an injection of TRH with increases in both TSH and PRL. © 1984.

Publication Source (Journal or Book title)

Domestic Animal Endocrinology

First Page

263

Last Page

268

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