Identifier

etd-04112016-102109

Degree

Master of Science (MS)

Department

Mechanical Engineering

Document Type

Restricted Thesis

Abstract

Thiol-acrylate materials have been demonstrated to have therapeutic potential as biocompatible scaffolds for bone tissue regeneration due to their osteoconductivity, biodegradability, and well-suited mechanical properties. This study connects the mechanical properties and stability of thiol-acrylate polymer with cell adhesion and proliferation of human adipose derived stromal cells. The polymer presented in this study, trimethylolpropane ethoxylate triacrylate-co-trimethylolpropane tris (3-mercaptopropionate) (TMPeTA-co-TMPTMP), was synthesized by an amine-catalyzed Michael addition reaction. Physical, mechanical, and chemical characterizations were performed on the polymeric scaffold, followed by preliminary in vitro cytocompatibility tests. Live/dead staining assays showed significant differences in cell adhesion for TMPeTA (692 and 912 MW). Collectively, these results highlight the potential for these thiol-acrylate based polymers to be a versatile, biocompatible scaffold for bone tissue engineering applications.

Date

2016

Document Availability at the Time of Submission

Student has submitted appropriate documentation to restrict access to LSU for 365 days after which the document will be released for worldwide access.

Committee Chair

Devireddy, Ram

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