Identifier

etd-04122010-092452

Degree

Master of Science (MS)

Department

Biomedical and Veterinary Medical Sciences - Veterinary Clinical Sciences

Document Type

Thesis

Abstract

To compare insertion temperatures and torques of Hydroxyapatite (HA) coated and uncoated 5.5 mm AO cortical screws in equine third metatarsal bones (MTIII) in vitro, and to compare insertion and extraction torques of HA coated and uncoated screws after 4, 8, 12 and 16 weeks of healing in equine third metacarpal bones (MCIII) in vivo. No significant temperature differences were recorded in cadaveric bones for AO and HA coated screws. Insertion torques were significantly higher for HA coated implants compared to uncoated screws. In vivo, the AO screws lost 50% of their initial stability within 4 weeks of healing and failed to gain stability over the next 12 weeks. The HA screws maintained stability (at 4 weeks), and roughly doubled (at 8 weeks) and tripled (at 12 weeks) their insertional torques over time. HA coated screws can safely be inserted in equine cortical bone. AO cortical stainless steel screws fail to maintain stability in equine cortical bone. The addition of HA coating to the screws enables active osseointegration over 3 months of healing, as indicated by significantly higher extractional torques after 8, 12 and 16 weeks respectively. Screw failure can occur under acute load and cyclic fatigue indicating the need for improved stability in the equine patient. HA coating, leading to active osseointegration, is commonly used in human implants for this purpose. Varying results in equine models led to guarded acceptance of implant coatings amongst equine surgeons. Our results support the osseointegrative properties of HA coated screws in horses.

Date

2010

Document Availability at the Time of Submission

Release the entire work immediately for access worldwide.

Committee Chair

Sod, Gary A., DVM, PhD

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