Identifier

etd-09182008-131849

Degree

Doctor of Philosophy (PhD)

Department

Chemistry

Document Type

Dissertation

Abstract

Chapter I introduced the background of phthalocyanines including its physical properties and various synthetic methods of free-base and metallo-phthalocyanines. The background of PDT and BNCT was introduced and the objective of ideal sensitizers was described. Chapter II described the synthesis and characterization of a series of pyridiloxy-substituted zinc phthalocyanines with different length of alkyl groups. Pyridiloxy-substituted silica phthalocyanines bearing different associated axial ligands, were alkylated with methyl or PEG chains. Biological study was performed on these cationic pyridiloxy-substituted zinc phthalocyanines. Chapter III introduced the synthesis and photophysical properties of A3B-type zinc phthalocyanines conjugated with one or two cobalta-carborane cages. They are highly soluble in polar solvents such as methanol, acetone, DMF and DMSO. Their absorption and emission properties are solvent-dependent, and had ~0.1 fluorescence quantum yields. These Pcs may have potential application as dual sensitizers in the PDT and BNCT treatment of tumors. Chapter IV introduced the synthesis and characterization of octa, tetra and dihdroxy-substituted phthalocyanines using different synthetic strategies. Chapter V introduced the synthesis and characterization of octaphosphonate-substituted zinc phthalocyanine.

Date

2008

Document Availability at the Time of Submission

Secure the entire work for patent and/or proprietary purposes for a period of one year. Student has submitted appropriate documentation which states: During this period the copyright owner also agrees not to exercise her/his ownership rights, including public use in works, without prior authorization from LSU. At the end of the one year period, either we or LSU may request an automatic extension for one additional year. At the end of the one year secure period (or its extension, if such is requested), the work will be released for access worldwide.

Committee Chair

M. Graca H. Vicente

Included in

Chemistry Commons

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