Doctor of Philosophy (PhD)
Chapter 1 contains an introduction to porphyrins and carboranylporphyrins, including their physical properties, history, methods of synthesis, medicinal applications, and an overview of recently published compounds. Chapter 2 contains the total synthesis of a series of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in boron neutron capture therapy (BNCT), including characterization by proton nuclear magnetic resonance spectroscopy, matrix-assisted time-of-flight mass spectroscopy, high resolution mass spectroscopy, UV-Vis spectrophotometry, X-ray crystallography, and melting point apparatus. Chapter 3 contains synthetic methods which were investigated as alternate routes to porphyrin synthesis and functionalization. Chapter 4 presents the in vitro biological evaluation of trimethylamine- and phosphonate-substituted carboranylporphyrins.
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Easson, Michael William, "Syntheses of trimethylamine- and phosphonate- substituted carboranylporphyrins for application in boron neutron cancer therapy" (2008). LSU Doctoral Dissertations. 1887.
M. Graca H. Vicente