Doctor of Philosophy (PhD)



Document Type



Four studies on vascular and exercise physiology are presented in this document. The 1st study examined the relationships between measures of fitness and FVF in 55 young [22.6 ± 3.5 years] adults. Estimated VO2peak correlated with arterial inflow (Ainf) [r=0.54; p=0.012] and resting venous outflow (Vout) [r=0.56; p=0.016]. Lastly, HG strength was associated with Vcap [r=0.57; p=0.007] and Vout [r=0.67; p=0.001]. The 2nd study examined the relationship between FVF and exercise tolerance (ExT) in 20 patients with HF [age: 59 ± 13 years] and 10 age-matched controls [age: 51 ± 16 years. The ExT was measured as the maximum walking distance (MWD) in 6 minutes. FVF [Ainf: HF 15.3 ± 6; controls 22 ± 6.7; Vcap: HF 1.4 ± 0.5; controls 2.0 ± 0.4; Vout: HF 24.5 ± 9.4; controls 33 ± 10 mL · 100 mL tissue-1 · min-1; and forearm vascular resistance: HF 7.8 ± 3; controls 4.6 ± 1.4U] indices and MWD [HF: 178 ± 65 m; controls: 562 ± 136m, P = .0001] were different between groups. Correlation analysis revealed significant associations between FVF indices and MWD. The 3rd study examined the effect of 25% (LO) and 75% (HI) of MVC short-term HG exercise training on FVF in 28 healthy men [Age:23±4.3]. The 4-week program consisted of non-dominant HG exercise performed 5 d/wk for 20-min. Training resulted in increased Ainf in the non-dominant arm in the LO and HI groups by 16.51% and 20.72%, respectively. The final study examined the time-course FVF adaptations to HG exercise training in 17 men [Age: 22.6 ± 3.5]. The HG exercise was performed in the non-dominant arm 5 d/wk for 20-min at 60% of MVC. The 2 X 5 ANOVA revealed arms X visits interaction for Ainf [p=0.02], while the LSD post-hoc demonstrated unilateral increase in Ainf following the 1st week. Additional 2 X 5 split-plot ANOVA tests revealed arms X visits interaction [p=0.04] for venous compliance (Vcomp) with LSD post-hoc demonstrating a decrease in trained arm Vcomp in visit 2 followed by an increase in visit 4 and return to baseline level at visit 5.



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Committee Chair

Welsch, Mike

Included in

Kinesiology Commons